Pterostilbene Protocol

Pterostilbene is a natural compound found in blueberries (9.9-15.1 mg/kg), grapes, and peanuts. It's closely related to resveratrol but has two key chemical differences (methoxy groups instead of hydroxyl groups) that make it far more bioavailable and effective. Whilst resveratrol requires massive doses because most gets broken down before it can work, pterostilbene is absorbed much better and stays active in your body longer.

Research shows pterostilbene has dramatically superior absorption - at the same dose, peak blood levels of pterostilbene are 36 times higher than resveratrol. Its oral bioavailability is 66.9% compared to just 29.8% for resveratrol, and it has a longer half-life (105 minutes versus 14 minutes). Over 75% of pterostilbene remains unchanged in the body, whilst resveratrol gets rapidly broken down.

The compound crosses the blood-brain barrier effectively, making it particularly interesting for brain health. Studies suggest pterostilbene addresses oxidative damage, inflammation, and cellular ageing whilst working with sirtuin proteins to enhance cellular resilience and longevity. Preclinical evidence shows potential for counteracting age-related cognitive decline and helping with memory, though human cognitive trials are still needed.

For blood pressure, a clinical trial of 80 people with high cholesterol found high-dose pterostilbene (125mg twice daily) significantly reduced both systolic blood pressure (-7.8 mmHg) and diastolic blood pressure (-7.3 mmHg). The diastolic reduction surpasses most alternative medicine therapies for blood pressure.

Reduces blood pressure substantially. Clinical trials show high-dose pterostilbene (250mg daily) lowers systolic pressure by 7.8 mmHg and diastolic by 7.3 mmHg, with the diastolic reduction being particularly impressive compared to other natural therapies. The blood pressure benefits were strong enough to offset increases in cholesterol when calculating cardiovascular risk scores.

Delivers far superior bioavailability compared to resveratrol, making it more practical for supplementation. With 36 times higher peak blood levels at equivalent doses and over 75% remaining active in your body (versus rapid breakdown of resveratrol), you get more benefit from smaller doses. The improved lipid solubility allows better tissue distribution and blood-brain barrier crossing.

Shows promise for brain health and cognitive decline, though human trials are still needed. Preclinical research demonstrates potential for counteracting age-related cognitive decline, improving memory consolidation, and possibly helping with neurodegenerative diseases like Alzheimer's. The compound crosses the blood-brain barrier and addresses oxidative damage, inflammation, and cellular senescence in brain tissue.

Provides wide-ranging health effects including antioxidant activity, anti-inflammatory benefits, and cellular protection. Studies show effects on glucose metabolism, cardiovascular health, and anti-ageing properties. The compound works through multiple pathways including Nrf2 activation and sirtuin engagement to support cellular resilience and metabolic balance.