NR Protocol

NAD+ is your body's master energy molecule, found in every single cell where it powers the mitochondria that convert food into usable energy.

As we age, NAD+ levels decline dramatically, which is why boosting them has become central to longevity research.

Nicotinamide Riboside (NR) is an efficient NAD+ precursor that your body readily converts into NAD+ through well-established pathways. NR is uniquely and orally bioavailable, meaning it gets into your system effectively when taken by mouth.

Research shows it was first identified as a NAD+ precursor that works consistently across species.

Unlike regular niacin, NR won't cause uncomfortable flushing or trigger certain receptors that can cause side effects.

Compared to NMN (another NAD+ booster), NR has more established safety data from human trials. The first clinical trial of NR began in 2016, launching serious research into its safety and effectiveness in people.

NR enhances oxidative metabolism by activating key cellular proteins (SIRT1 and SIRT3) that improve how your mitochondria function.

It actively supports mitochondrial biogenesis - essentially helping your body build new, healthier mitochondria and improve muscle cell development.

Research suggests NR may offer neuroprotective effects by addressing mitochondrial problems that contribute to brain degeneration.

It promotes your body's natural repair systems by activating proteins called sirtuins and PARPs, which are crucial for DNA maintenance and cellular health.

Multiple clinical trials have tested NR for conditions like Parkinson's disease, showing real therapeutic potential.

Use pharmaceutical-grade NR at appropriate doses with cycling periods to maximise NAD+ benefits while keeping your cells responsive to supplementation.