Fisetin Senolytic Protocol
A protocol using fisetin, a natural flavonoid with senolytic properties, meaning it helps clear out old, dysfunctional cells that build up with age and drive inflammation and aging.
Overview
As we age, some of our cells stop dividing but refuse to die properly, creating what researchers call senescent cells. These damaged cells accumulate with ageing and release inflammatory chemicals known as the senescence-associated secretory phenotype (SASP). These chemicals damage healthy nearby cells and drive chronic inflammation throughout the body. Fisetin is a natural compound found in strawberries and other fruits that researchers have identified as the most potent senolytic among tested natural compounds. This research field began in the 2010s when first senolytic drugs were discovered at Mayo Clinic. Fisetin works by targeting these problem cells for elimination while leaving healthy cells untouched.
Key Benefits
Clears senescent cells from the body and reduces the chronic inflammation they cause. May improve physical function and reduce frailty in older adults by removing cells that contribute to age-related decline. Research suggests potential for tissue rejuvenation and protection against multiple age-related diseases by targeting fundamental ageing processes. Clinical trials underway at Mayo Clinic and other institutions are testing safety and effectiveness in humans. Use high-quality fisetin supplements at precisely calculated doses with proper cycling protocols to maximise potential benefits whilst minimising side effects in this experimental therapeutic approach.