GlyNAC Protocol

GlyNAC is a combination of two amino acids - glycine and N-acetylcysteine (NAC) - which together serve as building blocks for glutathione, the most abundant antioxidant inside human cells. Glutathione levels decline progressively with age, contributing to cellular damage from free radicals, damaged cellular power plants (mitochondria), inflammation, and accelerated ageing. GlyNAC supplementation addresses this deficiency by providing both key building blocks required for efficient glutathione production.

Pioneering research from Baylor College of Medicine demonstrated that GlyNAC supplementation in older adults (aged 70-80 years) for 16 weeks improved glutathione levels, reduced cellular damage, enhanced mitochondrial function, and addressed multiple markers of ageing. This randomised, placebo-controlled trial established GlyNAC as safe and well-tolerated for promoting healthy ageing. Comprehensive reviews have documented GlyNAC's broad effects on metabolic health, muscle strength, cognitive decline, and body composition.

Improves muscle strength (grip strength), walking speed, and 6-minute walk distance in older adults, with a 36-week clinical trial showing that 24 weeks of GlyNAC supplementation significantly improved these measures compared to baseline. These functional improvements correlated with restored glutathione levels, reduced cellular damage, and enhanced mitochondrial function. Notably, benefits declined after stopping supplementation for 12 weeks, suggesting ongoing use is necessary to maintain effects.

Enhances cognitive performance using validated tests, with the same pilot trial documenting improvements alongside reductions in insulin resistance, blood vessel health problems, and DNA damage. Studies in aging populations have shown GlyNAC reverses brain glutathione deficiency, cellular damage, mitochondrial dysfunction, glucose uptake problems, inflammation, and brain chemical deficiencies - key contributors to age-related cognitive decline.

Corrects mitochondrial dysfunction by improving energy production and mitochondrial gene activity, demonstrating improvements accompanied by reductions in body fat, waist circumference, and inflammatory markers, suggesting widespread metabolic benefits. Research has shown GlyNAC addresses fundamental mechanisms of ageing by correcting glutathione deficiency and mitochondrial dysfunction. By combining the complementary mechanisms of glycine and NAC, GlyNAC provides a more effective approach to restoring glutathione than either compound alone.